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Standardised quality

Arkoroyal® ensures a Royal Jelly of Premium Quality, titrated in apalbumin-1 and in 10-HDA, a guarantee of quality and activity of our raw material.

Arkoroyal® Royal Jelly is naturally titrated to 2.5% in apalbumin, a marker of the imune activity

Leader and expert on its market, Arkopharma has been studying the composition of Royal Jelly for several years to understand this treasure and its mechanisms. In collaboration with a recognized Apidology laboratory, Arkopharma has identified apalbumin-1 as a major ingredient in Royal Jelly. Arkoroyal® Royal Jelly contains 2.5% of apalbumin-1, which corresponds to 9% on dry matter.

What are apalbumins?

Apalbumins are the major proteins in Royal Jelly. Apalbumin-1 is the most abundant and accounts for 45% of total proteins. It’s the most studied protein.


Apalbumin-1 is beneficial for bees thanks to its nutritional and antibacterial properties.


Royal Jelly contains at least 100 times more apalbumin than honey.
Fed exclusively on honey, a larva becomes a bee. Nourished exclusively with Royal Jelly, rich in apalbumin-1, a larva becomes queen and will live up to 40 times longer than its congeners.


Studies on apalbumin-1

Several authors identified apalbumin-1 as:

  • One of the markers of the immune activity of Royal Jelly  (the release of some immunity mediators such as TNF-alpha is multiplied by 16 thanks to apalbumin-1).
  • One of the freshness markers of Royal Jelly: it confirms the authenticity of Royal Jelly and substantiate its preservation over time.

According to the authors, apalbumin also has antimicrobial activity.

Arkoroyal® Royal Jelly is naturally titrated and standardised in 10-HDA: 1.4% min

What is 10-HDA?

Among the components of Royal Jelly, 10-HDA (10-hydroxy-2-decenoic acid) is a specific fatty acid of Royal Jelly. It is a compound that is of great interest to researchers because it has been identified to participate in the activity of Royal Jelly.

Arkoroyal® guarantees the standardisation of Royal Jelly in 10-HDA according to the ISO 12824 (2016) standard; and respects rules of strict formulation ensuring vials free from preservatives, chemical ingredients, colouring and alcohol.



Free of chemicals






Arkoroyal®: a certified quality system and regular checks


Arkopharma laboratories are certified ISO 22000 and our organic products have the  European Organic Farming label (certified by ECOCERT).

It ensures a standardised quality of our Royal Jelly, according to the ISO 12824:2016 standard and compliance with the regulations.

Moreover, with its 1st Label of Responsible Apiculture and its systematic controls on Royal Jelly, Arkopharma laboratories check the absence of:

  • more than 220 pesticide residues,
  • more than 60 antibiotic residues
    (e.g., chloramphenicol, nitrofurans, etc.).


Substances, residues of veterinary drugs (including antibiotics) Health risks
Chloramphenicol Antibiotic which, absorbed systemically, causes blood disorders (anaemia) and has a carcinogenic effect
Nitrofuran metabolites Risk of allergies, neurotoxicity, renal toxicity, etc.
- Streptomycin
- Tetracyclines 
- Sulfamides and trimethoprim
- Fluoroquinolones
- Macrolides
Risk of allergies, neurotoxicity, renal toxicity, etc.
- Amitraz
- Coumaphos
Risk of allergies, neurotoxicity, renal toxicity, etc.
- Phytosanitary residues (including pesticides) Sources of risk of hypothermia (decrease in body temperature), hypotension (decrease in blood pressure), bradycardia (slowing of heart rate)
Heavy metals 
- Lead 
- Cadmium 
- Arsenic 
- Mercury
Lead poisoning, cancer, gastrointestinal disorders, deregulation of the central nervous system
Polycyclic aromatic hydrocarbons 
(PAHs, Benzo(a)pyrene)
Microbiology  Risk of gastrointestinal disorders


Bibliographic sources:

Simúth J et al. Immunochemical approach to detection of adulteration in honey: physiologically active royal jelly protein stimulating TNF-alpha release is a regular component of honey. J Agric Food Chem. 2004 Apr 21;52(8):2154-8.

Fratini F, et al. Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiol Res 2016 Nov;192:130-141.

Majtán J, et al. The immunostimulatory effect of the recombinant apalbumin 1-major honeybee royal jelly protein-on TNFalpha release. Int Immunopharmacol 2006;6(2):269-78.

Šimúth J. Some properties of the main protein of honeybee (Apis mellifera) royal jelly. Apidologie 2001;32(1):69-80.

Sugiyama T, et al. Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses. Endocr Metab Immune Disord Drug Targets. 2012;12(4):368-76.